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Galectin Therapeutics galectin 3 inhibitor gb1107 administration
Galectin 3 Inhibitor Gb1107 Administration, supplied by Galectin Therapeutics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/galectin-3+inhibitors/gb1107/pm42298444-98-11-11
Average 86 stars, based on 1 article reviews
galectin 3 inhibitor gb1107 administration - by Bioz Stars, 2026-09
86/100 stars

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Functional Assay:

Article Title: Pathogenesis of Thyroid Cancer with Particular Emphasis on the Role of Anoikis.
Article Snippet: Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells.

Article Title: BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAF V600E -mutant glioma
Article Snippet: Quadruple treatment may increase toxicity, but pediatric patients - enriched for BRAF-mutant gliomas - may tolerate it better than adults, and dose reductions or sequential treatment combined with Galectin-3 inhibitors could help balance efficacy and safety.

Article Title: BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAF V600E -mutant glioma.
Article Snippet: 53 Quadruple treatment may increase toxicity, but pediatric patients - enriched for BRAFmutant gliomas - may tolerate it better than adults, and dose reductions or sequential treatment combined with Galectin-3 inhibitors could help balance efficacy and safety.

Article Title: Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets.
Article Snippet: Galectin-3 Inhibitors Galectin-3 is a glycoprotein that plays a crucial role in PF, particularly in mediating interactions between epithelial cells and fibroblasts.

Article Title: Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets.
Article Snippet: Inhibiting Galectin-3 has been shown to disrupt the transmission of fibrotic signals and mitigate the fibrotic response following epithelial cell injury [151].

Article Title: AI-Driven Discovery of Brain-Penetrant Galectin-3 Inhibitors for Alzheimer's Disease Therapy.
Article Snippet: AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer’s disease therapy Xueyan Liu a,b,c,1, Jiexin Xu a,1, Shuping Zheng d,1, Yaoyao Yang b, Yuchong Xie b, Jinyu Liu b, Jian Zhong b, Huiyao Zhang b, Jiajing Chen b, Chaoxian Dai b, Dingyan Wang e, Jiewei Luo f, Xiaochun Chen g,***, Feisheng Zhong a,c,**, Zu-Cheng Ye b,* a School of Pharmacy, Fujian Medical University, Fuzhou, China b Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China c Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou, China d Public Technology Service Center, Fujian Medical University, Fuzhou, China e Lingang Laboratory, Shanghai, China f Department of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China g Department of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology and Institute of Neuroscience, Fujian Medical University, Fuzhou, China A R T I C L E I N F O Keywords: Galectin-3 Cognitive function Alzheimer’s disease Neuroinflammation Microglial activation A B S T R A C T Galectin-3 (Gal-3) has emerged as a critical regulator of neuroinflammation and a promising therapeutic target for Alzheimer’s disease (AD).

Article Title: Discovery of Galactopyranose-1-carboxamides as a New Class of Small, Novel, Potent, Selective, and Orally Active Galectin-3 Inhibitors.
Article Snippet: Class of Small, Novel, Potent, Selective, and Orally Active Galectin-3 Inhibitors Cornelia Zumbrunn,* Luboš Remen, Christoph P. Sager, Corinna Grisostomi, Christina Stamm, Daniela Krüsi, Sven Glutz, Gunther Schmidt, Oliver Nayler, Marc Iglarz, Aengus Mac Sweeney, Alain Chambovey, Manon Müller, Celia Mueller, Geoffroy Bourquin, Solange Meyer, Eva Hühn, Christophe Cattaneo, Magali Vercauteren, John Gatfield, and Martin H. Bolli

Article Title: Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets.
Article Snippet: Personalized medicine will benefit from patient stratification based on single-cell and spatial omics data, guiding tailored treatments like Galectin-3 inhibitors for SCGB3A2+ patients.

Activation Assay:

Article Title: Pathogenesis of Thyroid Cancer with Particular Emphasis on the Role of Anoikis.
Article Snippet: Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells.

Article Title: BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAF V600E -mutant glioma
Article Snippet: Quadruple treatment may increase toxicity, but pediatric patients - enriched for BRAF-mutant gliomas - may tolerate it better than adults, and dose reductions or sequential treatment combined with Galectin-3 inhibitors could help balance efficacy and safety.

Article Title: BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAF V600E -mutant glioma.
Article Snippet: 53 Quadruple treatment may increase toxicity, but pediatric patients - enriched for BRAFmutant gliomas - may tolerate it better than adults, and dose reductions or sequential treatment combined with Galectin-3 inhibitors could help balance efficacy and safety.

Article Title: Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets.
Article Snippet: Galectin-3 Inhibitors Galectin-3 is a glycoprotein that plays a crucial role in PF, particularly in mediating interactions between epithelial cells and fibroblasts.

Article Title: Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets.
Article Snippet: Inhibiting Galectin-3 has been shown to disrupt the transmission of fibrotic signals and mitigate the fibrotic response following epithelial cell injury [151].

Article Title: AI-Driven Discovery of Brain-Penetrant Galectin-3 Inhibitors for Alzheimer's Disease Therapy.
Article Snippet: AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer’s disease therapy Xueyan Liu a,b,c,1, Jiexin Xu a,1, Shuping Zheng d,1, Yaoyao Yang b, Yuchong Xie b, Jinyu Liu b, Jian Zhong b, Huiyao Zhang b, Jiajing Chen b, Chaoxian Dai b, Dingyan Wang e, Jiewei Luo f, Xiaochun Chen g,***, Feisheng Zhong a,c,**, Zu-Cheng Ye b,* a School of Pharmacy, Fujian Medical University, Fuzhou, China b Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China c Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou, China d Public Technology Service Center, Fujian Medical University, Fuzhou, China e Lingang Laboratory, Shanghai, China f Department of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China g Department of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology and Institute of Neuroscience, Fujian Medical University, Fuzhou, China A R T I C L E I N F O Keywords: Galectin-3 Cognitive function Alzheimer’s disease Neuroinflammation Microglial activation A B S T R A C T Galectin-3 (Gal-3) has emerged as a critical regulator of neuroinflammation and a promising therapeutic target for Alzheimer’s disease (AD).

Article Title: Discovery of Galactopyranose-1-carboxamides as a New Class of Small, Novel, Potent, Selective, and Orally Active Galectin-3 Inhibitors.
Article Snippet: Class of Small, Novel, Potent, Selective, and Orally Active Galectin-3 Inhibitors Cornelia Zumbrunn,* Luboš Remen, Christoph P. Sager, Corinna Grisostomi, Christina Stamm, Daniela Krüsi, Sven Glutz, Gunther Schmidt, Oliver Nayler, Marc Iglarz, Aengus Mac Sweeney, Alain Chambovey, Manon Müller, Celia Mueller, Geoffroy Bourquin, Solange Meyer, Eva Hühn, Christophe Cattaneo, Magali Vercauteren, John Gatfield, and Martin H. Bolli

Article Title: Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets.
Article Snippet: Personalized medicine will benefit from patient stratification based on single-cell and spatial omics data, guiding tailored treatments like Galectin-3 inhibitors for SCGB3A2+ patients.

Drug discovery:

Article Title: Pathogenesis of Thyroid Cancer with Particular Emphasis on the Role of Anoikis.
Article Snippet: Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells.

Article Title: BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAF V600E -mutant glioma
Article Snippet: Quadruple treatment may increase toxicity, but pediatric patients - enriched for BRAF-mutant gliomas - may tolerate it better than adults, and dose reductions or sequential treatment combined with Galectin-3 inhibitors could help balance efficacy and safety.

Article Title: BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAF V600E -mutant glioma.
Article Snippet: 53 Quadruple treatment may increase toxicity, but pediatric patients - enriched for BRAFmutant gliomas - may tolerate it better than adults, and dose reductions or sequential treatment combined with Galectin-3 inhibitors could help balance efficacy and safety.

Article Title: Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets.
Article Snippet: Galectin-3 Inhibitors Galectin-3 is a glycoprotein that plays a crucial role in PF, particularly in mediating interactions between epithelial cells and fibroblasts.

Article Title: Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets.
Article Snippet: Inhibiting Galectin-3 has been shown to disrupt the transmission of fibrotic signals and mitigate the fibrotic response following epithelial cell injury [151].

Article Title: AI-Driven Discovery of Brain-Penetrant Galectin-3 Inhibitors for Alzheimer's Disease Therapy.
Article Snippet: AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer’s disease therapy Xueyan Liu a,b,c,1, Jiexin Xu a,1, Shuping Zheng d,1, Yaoyao Yang b, Yuchong Xie b, Jinyu Liu b, Jian Zhong b, Huiyao Zhang b, Jiajing Chen b, Chaoxian Dai b, Dingyan Wang e, Jiewei Luo f, Xiaochun Chen g,***, Feisheng Zhong a,c,**, Zu-Cheng Ye b,* a School of Pharmacy, Fujian Medical University, Fuzhou, China b Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China c Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou, China d Public Technology Service Center, Fujian Medical University, Fuzhou, China e Lingang Laboratory, Shanghai, China f Department of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China g Department of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology and Institute of Neuroscience, Fujian Medical University, Fuzhou, China A R T I C L E I N F O Keywords: Galectin-3 Cognitive function Alzheimer’s disease Neuroinflammation Microglial activation A B S T R A C T Galectin-3 (Gal-3) has emerged as a critical regulator of neuroinflammation and a promising therapeutic target for Alzheimer’s disease (AD).

Article Title: Discovery of Galactopyranose-1-carboxamides as a New Class of Small, Novel, Potent, Selective, and Orally Active Galectin-3 Inhibitors.
Article Snippet: Class of Small, Novel, Potent, Selective, and Orally Active Galectin-3 Inhibitors Cornelia Zumbrunn,* Luboš Remen, Christoph P. Sager, Corinna Grisostomi, Christina Stamm, Daniela Krüsi, Sven Glutz, Gunther Schmidt, Oliver Nayler, Marc Iglarz, Aengus Mac Sweeney, Alain Chambovey, Manon Müller, Celia Mueller, Geoffroy Bourquin, Solange Meyer, Eva Hühn, Christophe Cattaneo, Magali Vercauteren, John Gatfield, and Martin H. Bolli

Article Title: Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets.
Article Snippet: Personalized medicine will benefit from patient stratification based on single-cell and spatial omics data, guiding tailored treatments like Galectin-3 inhibitors for SCGB3A2+ patients.



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Image Search Results


Compartment-specific functions of Galectin-3 and therapeutic targeting strategies in prostate cancer.

Journal: Current Oncology

Article Title: Prostate Cancer Biomarkers with a Focus on Galectin-3: Emerging Clinical and Therapeutic Implications

doi: 10.3390/curroncol33050280

Figure Lengend Snippet: Compartment-specific functions of Galectin-3 and therapeutic targeting strategies in prostate cancer.

Article Snippet: Melanoma & HNSCC , Immune Escape: Gal-3 acts as a negative immune checkpoint, blocking anti-PD-1 antibody binding to T-cells. , Belapectin + Pembrolizumab , Small molecule Galectin-3 inhibitor , Phase I study showed objective response rates of 50% (melanoma) and 33% (HNSCC). Demonstrates that Gal-3 inhibitors may enhance immunotherapy by reversing immune suppression [ , ]. .

Techniques:

Compartment-specific functions of Galectin-3 and therapeutic targeting strategies in prostate cancer.

Journal: Current Oncology

Article Title: Prostate Cancer Biomarkers with a Focus on Galectin-3: Emerging Clinical and Therapeutic Implications

doi: 10.3390/curroncol33050280

Figure Lengend Snippet: Compartment-specific functions of Galectin-3 and therapeutic targeting strategies in prostate cancer.

Article Snippet: Lung & Pancreatic Cancer , KRAS Addiction: Gal-3 supports pro-survival pathways in KRAS-driven tumors. , GB1107 , Novel small molecule Galectin-3 inhibitor , Identified as a druggable vulnerability in hard-to-treat tumors, showing Gal-3 as a key mediator of oncogenic signaling beyond the AR pathway [ ]. .

Techniques: